Compositions capable of specifically binding particular human antigen presenting molecule/pathogen-derived antigen complexes and uses thereof

摘要

A composition-of-matter comprising an antibody or antibody fragment including an antigen-binding region capable of specifically binding an antigen-presenting portion of a complex composed of a human antigen-presenting molecule and an antigen derived from a pathogen is disclosed.

主权项

1. A composition-of-matter comprising a soluble antibody including an antigen-binding region capable of specifically binding a complex composed of a human antigen-presenting molecule and an MHC-restricted peptide derived from a pathogen, wherein said human antigen-presenting molecule is a single chain antigen-presenting molecule, wherein said binding of said antibody to said complex is characterized by an affinity having a dissociation constant from the range of 5×10−8 molar to 5×10−9 molar, wherein the antibody does not bind the human antigen-presenting molecule in an absence of the MHC-restricted peptide derived from the pathogen, and wherein the antibody does not bind the MHC-restricted peptide derived from the pathogen in an absence of the human antigen-presenting molecule, and whereas a monovalent or divalent configuration of said soluble antibody binds a complex comprising said MHC-restricted peptide when naturally presented on a cell.