Agent for the treatment and/or prophylaxis of an autoimmune disease and for the formation of regulatory T cells

摘要

The present invention relates to an agent for the treatment and/or prophylaxis of an autoimmune disease, an agent for the formation of regulatory T cells (TReg) in an organism and various methods in which the agents according to the invention are used.

主权项

1. A method for the treatment and/or prevention of the worsening of an autoimmune disease in an organism, the method comprising:
(a) administering a mutein of human interleukin-2 (hIL-2 mutein) to the organism, wherein said hIL-2 mutein has an amino acid substitution in at least one of the positions 20, 88 or 126, numbered in accordance with the hIL-2 wild type sequence as set forth in SEQ ID NO: 1; and (b) if necessary, repeating step (a), wherein the autoimmune disease is type I diabetes, multiple sclerosis, or systemic lupus erythematosus, and wherein the administration induces regulatory T cells in the organism.