主权项 |
1. A compound of the formula I: wherein: A is selected from the group consisting of phenyl, naphthyl and heteroaryl; X is N or CH; R1a, R1b and R1c are independently selected from the group consisting of:
(1) hydrogen,(2) halogen,(3) hydroxyl,(4) —(C═O)m—On—C1-6alkyl, where m is 0 or 1, n is 0 or 1 (wherein if m is 0 or n is 0, a bond is present) and where the alkyl is unsubstituted or substituted with one or more substituents selected from R4,(5) —(C═O)m—On—C3-6cycloalkyl, where the cycloalkyl is unsubstituted or substituted with one or more substituents selected from R4,(6) —(C═O)m—C2-4alkenyl, where the alkenyl is unsubstituted or substituted with one or more substituents selected from R4,(7) —(C═O)m—C2-4alkynyl, where the alkynyl is unsubstituted or substituted with one or more substituents selected from R4,(8) —(C═O)m—On-phenyl or —(C═O)m—On-naphthyl, where the phenyl or naphthyl is unsubstituted or substituted with one or more substituents selected from R4,(9) —(C═O)m—On-heterocycle, where the heterocycle is unsubstituted or substituted with one or more substituents selected from R4,(10) —(C═O)m—NR10R11, wherein R10 and R11 are independently selected from the group consisting of:
(a) hydrogen,(b) C1-6alkyl, which is unsubstituted or substituted with R4,(c) C3-6alkenyl, which is unsubstituted or substituted with R4,(d) C3-6alkynyl, which is unsubstituted or substituted with R4,(e) C3-6cycloalkyl which is unsubstituted or substituted with R4,(f) phenyl, which is unsubstituted or substituted with R4, and(g) heterocycle, which is unsubstituted or substituted with R4,(11) —S(O)2—NR10R11,(12) —S(O)q—R12, where q is 0, 1 or 2 and where R12 is selected from the definitions of R10 and R11,(13) —CO2H,(14) —CN, and(15) —NO2; R3 is selected from C1-6alkyl and C3-6cycloalkyl, which is unsubstituted or substituted with one or more substituents selected from R4; R4 is selected from the group consisting of:
(1) hydroxyl,(2) halogen,(3) C1-6alkyl,(4) —C3-6cycloalkyl,(5) —O—C1-6alkyl,(6) —O(C═O)—C1-6alkyl,(7) —NH2,(8) —NH—C1-6alkyl,(9) —NO2,(10) phenyl,(11) —CO2H, and(12) —CN; R5 is selected from the group consisting of:
(1) hydrogen,(2) halogen,(3) —CN,(4) —(C═O)—O—C1-6alkyl, which is unsubstituted or substituted with halogen or phenyl, and(5) C1-6alkyl, which is unsubstituted or substituted with halogen or phenyl; R6 is selected from the group consisting of:
(1) hydrogen,(2) halogen,(3) —CN,(4) —(C═O)—O—C1-6alkyl, which is unsubstituted or substituted with halogen or phenyl, and(5) C1-6alkyl, which is unsubstituted or substituted with halogen or phenyl; R7 is selected from the group consisting of:
(1) hydrogen, and(2) C1-6alkyl; or a pharmaceutically acceptable salt thereof. |