Methods of regulating angiogenesis by administering agents which increase apoB-100 polypeptide

摘要

A method of treating an angiogenesis related disease or disorder in a subject in need thereof is disclosed. The method comprises administering to the subject a therapeutically effective amount of an agent which regulates an amount of apolipoprotein B (ApoB), and/or an ability of ApoB to transcriptionally control vascular endothelial growth factor receptor 1 (VEGFR1).

主权项

1. A method of treating cancer in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a recombinant apolipoprotein B (ApoB) polypeptide comprising SEQ ID NO: 34 and capable of transcriptionally upregulating VEGFR1-, thereby treating the cancer.