| 发明名称 |
ANTIBODIES SPECIFICALLY BINDING TO HER3 |
| 摘要 |
The present invention relates to isolated antibodies, or an antigen portions thereof, which bind to human HER3. The novel antibodies are of great utility since they allow for the sensitive and specific detection of human HER3. Detection of human HER3 is, e.g., possible in a tissue sample, even when such tissue sample is a formalin-fixed paraffin embedded tissue (FFPET) sample. |
| 申请公布号 |
US2017096487(A1) |
申请公布日期 |
2017.04.06 |
| 申请号 |
US201615083686 |
申请日期 |
2016.03.29 |
| 申请人 |
Roche Diagnostics Operations, Inc. ;Ventana Medical Systems, Inc. |
发明人 |
Soukupova Monika;Schraeml Michael;Bossenmaier Birgit;Roche Patrick C.;Gerg Michael;Dziadek Sebastian |
| 分类号 |
C07K16/28;G01N33/574;C07K16/30;G01N33/74;G01N1/30 |
主分类号 |
C07K16/28 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An isolated antibody, or an antigen binding portion thereof, which binds to human HER3, wherein
the heavy chain variable domain comprises a CDR1H region comprising the amino acid sequence of SEQ ID NO: 1, a CDR2H region comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 2 and SEQ ID NO: 3 and a CDR3H region comprising the amino acid sequence of SEQ ID NO: 4, and the light chain variable domain comprises a CDR1L region comprising the amino acid sequence of SEQ ID NO: 5, a CDR2L region comprising the amino acid sequence selected from the group consisting of SEQ ID NO: 6 and SEQ ID NO: 7, and a CDR3L region comprising the amino acid sequence of SEQ ID NO: 8. |
| 地址 |
Indianapolis IN US |
