Compositions For An Injectable, In Situ Forming Neuroscaffold And Methods Of Using The Same

摘要

Disclosed are injectable, biodegradable neuroscaffolds formed in situ by self-assembling biodegradable polymeric microparticles, nanoparticles, or any combination thereof, via copper-free click chemistry or Michael-type addition coupling reactions. The injectable, biodegradable neuroscaffolds provide 3-D structural support, neuroprotection, and/or subsequent regeneration in a subject with a spinal cord injury or a focal neurological disorder.

主权项

1. An injectable, biodegradable neuroscaffold formed in situ by the self-assembly of surface-functionalized biodegradable, polymeric microparticles, nanoparticles, or any combination thereof comprising at least one terminal functional group moiety that is capable of undergoing a covalent cross-linking reaction with at least one other terminal functional group moiety of said microparticles, nanoparticles, or a combination thereof via
copper-free click chemistry; or, Michael-type addition, wherein the resulting neuroscaffold comprises at least one reducible, hydrolytically cleavable, or enzymatically cleavable bond under physiologically relevant conditions; and, wherein the resulting neuroscaffold comprises mechanical properties that are controlled by performing the cross-linking in the presence or absence of a functionalized linker or spacer moiety comprising at least two terminal functional group moieties capable of undergoing said covalent cross-linking reactions.