ALKYNYL INDAZOLE DERIVATIVE AND USE THEREOF

摘要

The main object of the present invention is to provide a novel compound which has a VEGF receptor tyrosine kinase inhibitory activity and is useful as an active ingredient for the treatment of diseases accompanying angiogenesis or edema, for example, age-related macular degeneration or the like.;The present invention includes, for example, an alkynyl indazole derivative represented by the following general formula (I), a pharmaceutical acceptable salt thereof, and a medicine containing thereof.;

主权项

1. An alkynyl indazole derivative represented by the following general formula (I):wherein
R1 represents a lower alkyl; X and Y are the same or different and each represents CH or N, with the proviso that X and Y are not simultaneously N; and Z is a group represented by the following general formula (a):wherein
R2 represents a lower alkyl which may have a substituent, n is an integer of 1 to 7; and A is a partial structure represented by the following formula:or a pharmaceutically acceptable salt thereof.