摘要 |
Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, or pharmaceutically acceptable salts thereof, compositions thereof, and methods of their use. The condition or disorder mediated by HDAC comprises a neurodegenerative pathology. Accordingly, also provided is a method of treating a neurodegenerative pathology mediated by HDAC in a subject in need of such a treatment, comprising administering to the subject a therapeutically effective amount of at least one compound, or pharmaceutically acceptable salt thereof, described herein. |
申请人 |
CHDI Foundation, Inc. |
发明人 |
DOMINGUEZ, Celia;MUN OZ-SANJUAN, Ignacio;LUCKHURST, Christopher A.;ALLEN, Daniel R.;RAPHY, Gilles;BÛRLI, Roland W.;BRECCIA, Perla;HAUGHAN, Alan F.;WISHART, Grant;HUGHES, Samantah J.;JARVIS, Rebecca E.;VATER, Huw D.;PENROSE, Stephen D.;WALL, Michael;STOTT, Andrew J.;SAVILLE-STONES, Elizabeth |