Molecularly imprinted carbon

摘要

Preparation of a molecularly imprinted carbon is described. The molecularly imprinted carbon has a surface that is imprinted on the molecular level for a specific template molecule of interest, making it highly selective for analytes corresponding to at least a portion of the template molecule. Devices including the molecularly imprinted carbon and their use in methods of detecting analytes are also described. As an example, dibutyl butylphosphonate (DBBP), a surrogate for chemical warfare agents, was used as a template molecule. Electrospun molecularly imprinted SU-8 and pyrolyzed polymer (PP) solid-phase microextraction (SPME) devices were prepared; their ability to preferentially extract DBBP from an aqueous matrix, with and without interferences present, was evaluated via comparison with non-imprinted SU-8 and PP SPME fibers. The electrospun devices demonstrated a higher selectivity for DBBP, as evidenced by their extraction time profiles. The MI-SPME fibers tested extracted at least 60% more DBBP than their non-imprinted counterparts.

主权项

1. A composition comprising a nongraphitizable molecularly imprinted carbon derived from a molecularly imprinted polymer; wherein a portion of the molecularly imprinted carbon has a shape corresponding to the shape of at least a portion of a template molecule; and wherein the molecularly imprinted carbon has an affinity for the template molecule, wherein the molecularly imprinted carbon is formed by pyrolysis of the molecularly imprinted polymer in an inert or reducing atmosphere.