Analyzing a washout period characteristic for psychiatric disorder therapy delivery

摘要

A characteristic of a washout period following the delivery of therapy to a patient according to a therapy program may be determined based on a physiological parameter of the patient. A washout period includes the period of time during which a carryover effect from the therapy dissipates. The washout period characteristic may include, for example, a duration of the washout period, an amplitude or a trend in a physiological signal during the washout period or a power level or a ratio of power levels in frequency bands of the physiological signal. In some embodiments, washout period characteristics associated with a plurality of therapy programs may be used to compare the programs. In other embodiments, a washout period characteristic may be used to determine a mood state of the patient and, in some cases, modify a therapy program. Monitoring a washout period may also be useful for timing therapy program trials.

主权项

1. A method comprising:
with a medical device, delivering therapy to a patient according to a therapy program during a first period, wherein the therapy program defines a value for at least one therapy parameter for managing a psychiatric condition of the patient; monitoring a physiological signal of the patient during a second period immediately following the first period; automatically determining a characteristic of a washout period based on the monitored physiological signal, wherein the washout period occurs during the second period, and wherein at least one carryover effect from the therapy substantially dissipates during the washout period; determining a patient mood state or a mood state probability based on the characteristic of the washout period; detecting a change in the physiological signal from a baseline state of the physiological signal during the second period; and determining when the physiological signal returns to the baseline state during the second period, wherein a time period for the physiological signal to return to the baseline state during the second period defines the washout period.