| 发明名称 | Treating cardiovascular or renal diseases | ||
| 摘要 | This document provides methods and materials for treating cardiovascular and/or renal diseases. For example, AAV9 vectors designed to express natriuretic polypeptides, nucleic acid molecules encoding natriuretic polypeptides, methods for making AAV9 vectors, and methods for using such vectors or molecules to treat cardiovascular and/or renal diseases are provided. | ||
| 申请公布号 | US9611305(B2) | 申请公布日期 | 2017.04.04 |
| 申请号 | US201314370554 | 申请日期 | 2013.01.04 |
| 申请人 | Mayo Foundation for Medical Education and Research | 发明人 | Ikeda Yasuhiro;Russell Stephen James;Cataliotti Alessandro;Burnett, Jr. John C.;Tonne Jason M. |
| 分类号 | C07K14/47;C07K14/58;C12N15/86;C12N7/00 | 主分类号 | C07K14/47 |
| 代理机构 | Fish & Richardson P.C. | 代理人 | Fish & Richardson P.C. |
| 主权项 | 1. A method for improving cardiac function in a mammal with polycystic kidney disease, wherein said method comprises administering an AAV9 vector to said mammal with polycystic kidney disease, wherein said AAV9 vector comprises a nucleic acid sequence encoding a natriuretic polypeptide, and wherein cardiac function is improved at least two months following said administration when said AAV9 vector is administered to said mammal with polycystic kidney disease. | ||
| 地址 | Rochester MN US | ||