| 摘要 |
The present invention provides a compound of formula (I):;
or a pharmaceutically acceptable salt, solvate, or amino acid conjugate thereof, wherein R1, R2, R3, R4, R5, and R6 are as described herein. The present invention relates generally to selective FXR agonists and to methods of making and using them. |
| 主权项 |
1. A compound of formula I:or a pharmaceutically acceptable salt or amino acid conjugate thereof, wherein:
R1 is beta-hydroxyl; R2 is hydrogen, hydroxyl, alkyl, or halogen, wherein said alkyl is unsubstituted or substituted with one or more Ra; R3 is hydrogen, hydroxyl, alkyl, or halogen, wherein said alkyl is unsubstituted or substituted with one or more Rb; R4 is alkyl, alkenyl, alkynyl, or halogen, wherein said alkyl is unsubstituted or substituted with one or more Rc; Ra, Rb, and Rc are each independently halogen or hydroxyl; R5 is hydroxyl, OSO3H, OSO3−, O(CO)CH3, OPO3H2, OPO32−, or hydrogen; and R6 is hydroxyl, OSO3H, OSO3−, O(CO)CH3, OPO3H2, OPO32−, or hydrogen; or taken together R5 and R6 with the carbon atom to which they are attached form a carbonyl. |
