| 摘要 |
Disclosed are 2-substituted cephem compounds of formula (I), wherein the substituents are as defined in the specification. The compounds have a wide antimicrobial spectrum, in particular exhibit potent antimicrobial activity against beta-lactamase producing Gram negative bacteria. An example of a compound of formula (I) is: (4S, 6R, 7R)-7- ((Z)-2- (2-aminothiazol-4-yl )-2-(((2-carboxypropan-2-yl)oxy)imino)acetamido)-3-((4-((6,7-dihydroxy-4-oxo-1,4-dihydroquinoline-3-carboxamido)methyl)-1-azabicyclo[2.2.1]heptan-1-ium-1-yl)methyl)-4-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate |
