发明名称 |
CONJUGATED ANTISENSE COMPOUNDS AND THEIR USE |
摘要 |
The present disclosure provides duplexes comprising a first oligomeric compound and a second oligomeric compound wherein the second oligomeric compound comprises a conjugate group. In certain embodiments, the duplex modulates the amount or activity of a target nucleic acid in extra hepatic tissues and/or extra hepatic cells. In certain embodiments, the duplex modulates the amount or activity of a target nucleic acid in hepatic tissues and/or hepatic cells. |
申请公布号 |
WO2017053999(A1) |
申请公布日期 |
2017.03.30 |
申请号 |
WO2016US53836 |
申请日期 |
2016.09.26 |
申请人 |
IONIS PHARMACEUTICALS, INC. |
发明人 |
SETH, Punit, P.;OESTERGAARD, Michael;SWAYZE, Eric, E. |
分类号 |
C12N15/113;A61K31/7088;A61K31/712 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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