STRIP FOR HIGH-SENSITIVITY LATERAL FLOW IMMUNOASSAY BASED ON SURFACE-ENHANCED RAMAN SCATTERING AND DETECTION METHOD USING SAME

摘要

The present invention relates to a surface-enhanced Raman scattering (SERS) lateral flow immunoassay strip comprising: a sample pad, into which a sample comprising a target material is introduced; a conjugate pad comprising a hollow metal nanoprobe for surface-enhanced Raman scattering, on which an antibody that can be coupled to the target material and a Raman marker are immobilized; and a detection pad comprising a detection area, to which a secondary antibody is fixed, the second antibody being capable of being coupled to the target material coupled to the hollow metal nanoprobe. Use of the SERS-based lateral flow immunoassay strip according to the present invention simultaneously enables high-sensitivity quantitative analysis and qualitative analysis from Raman signal measurement that follows the concentration of the target material.