发明名称 |
OXOPIPERAZINE HELIX MIMETICS FOR CONTROL OF HYPOXIA-INDUCIBLE GENE EXPRESSION |
摘要 |
The present invention relates to oxopiperazines that mimic helix αB of the C-terminal transactivation domain of HIF1α. Also disclosed are pharmaceutical compositions containing these oxopiperazines and methods of using these oxopiperazines (e.g., to reduce gene transcription, treat or prevent disorders mediated by interaction of HIFla with CREB-binding protein and/or p300, reduce or prevent angiogenesis in a tissue, induce apoptosis, and decrease cell survival and/or proliferation). |
申请公布号 |
EP3145921(A2) |
申请公布日期 |
2017.03.29 |
申请号 |
EP20150795595 |
申请日期 |
2015.05.20 |
申请人 |
New York University |
发明人 |
ARORA, Paramjit S.;LAO, Brooke, Bullock;BONNEAU, Richard;DREW, Kevin |
分类号 |
C07D401/06 |
主分类号 |
C07D401/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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