| 发明名称 | Treatment and prevention of malaria | ||
| 摘要 | There are provided antigens, vectors encoding the antigens, and antibodies and other binding compounds to the antigens and uses thereof in the prevention or treatment of malaria. In particular, compositions are provided comprising a Reticulocyte-binding protein Homologue 5 (PfRH5) antigen having at least 90% identity with SEQ ID NO: 1, or a fragment thereof; or which comprise a viral vector that expresses PfRH5 antigen having at least 90% identity with SEQ ID NO: 2, or a fragment thereof. | ||
| 申请公布号 | US9603916(B2) | 申请公布日期 | 2017.03.28 |
| 申请号 | US201514936309 | 申请日期 | 2015.11.09 |
| 申请人 | Oxford University Innovation Limited | 发明人 | Douglas Alexander;Draper Simon;Hill Adrian;Williams Andrew;Illingworth Joseph |
| 分类号 | A61K39/015;C07K16/20;A61K39/39;C07K14/445;C12N15/86;C12N7/00;C12N15/115;A61K39/00 | 主分类号 | A61K39/015 |
| 代理机构 | Nevrivy Patent Law Group P.L.L.C. | 代理人 | Nevrivy Patent Law Group P.L.L.C. |
| 主权项 | 1. A viral vector or DNA plasmid that expresses PfRH5 antigen having at least 95% sequence identity with SEQ ID NO:2, wherein said PfRH5 antigen lacks the N-terminal signal peptide of PfRH5, wherein the N-terminal signal peptide corresponds to amino acid residues 1 to 25 of SEQ ID NO: 1. | ||
| 地址 | Oxford GB | ||