| 主权项 |
1. A compound of the formula I:I or an enantiomer, diastereomer, racemate, or a pharmaceutically acceptable salt thereof, wherein each R1 is independently selected from the group consisting of H, —OH, —COR4, —COOR4, —OCOOR4, —OCON(R4)2, —(C1-C16)alkylene-COOR4, —CN, —NO2, —SH, —SR4, —(C1-C16)alkyl, —O—(C1-C16)alkyl, —N(R4)2, —CON(R4)2, —SO2R4, —SO2NHR4, —S(═O)R4, and a nitric oxide donor group of the formula —X1—X2—X3, wherein X1 is absent or selected from the group consisting of —O—, —S— and —NH—; X2 is absent or is (C1-C20)alkylene optionally substituted by one or more —ONO2 groups; and X3 is —NO or —ONO2, provided that at least one R1 group is a nitric oxide donor group; each R2 is independently selected from the group consisting of (C1-C16)alkyl, (C2-C16)alkenyl, and (C2-C16)alkynyl; R3 is selected from the group consisting of (C1-C10)alkyl, (C3-C10)cycloalkyl, (C6-C14)aryl, and 4-12-membered heterocyclyl, each of which may optionally be substituted with —OH, —COR5, —COOR5, —(C1-C8)alkylene-COOR5, —CN, —NO2, —(C1-C8)alkyl, —O—(C1-C8)alkyl, —N(R5)2, —CON(R5)2, —SO2R5, —SO2NHR5, or —S(═)R5; each R4 is independently selected from the group consisting of H, (C1-C8)alkyl, (C3-C10)cycloalkyl, (C6-C14)aryl, and 4-12-membered heterocyclyl, each of which other than H may optionally be substituted with —OH, —COR5, —COOR5, —OCOOR5, —OCON(R5)2, —(C1-C8)alkylene-COOR5, —CN, —NO2, —SH, —SR5, —(C1-C8)alkyl, —O—(C1-C8)alkyl, —N(R5)2, —CON(R5)2, —SO2R5, —SO2NHR5, or —S(═O)R5; each R5 is independently selected from the group consisting of H, (C1-C8)alkyl, (C3-C10)cycloalkyl, (C6-C14)aryl, and 4-12-membered heterocyclyl; and n is 1, 2 or 3. |
