Compounds and uses thereof for the modulation of hemoglobin

摘要

Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.

主权项

1. A compound selected from the group consisting of or an N oxide thereof, wherein, R14 is C1-C6 alkyl, C3-C8 cycloalkyl, COR15 or COOR15; R15 is optionally substituted C1-C6 alkyl, optionally substituted C6-C10 aryl, optionally substituted 5-10 membered heteroaryl containing up to 5 ring heteroatoms, or optionally substituted 4-10 membered heterocycle containing up to 5 ring heteroatoms, wherein the heteroatom is selected from the group consisting of O, N, S, and oxidized forms of N and S; x is 0, 1, or 2; and m is 0, 1 or 2.