| 摘要 |
The invention provides compounds, compositions, and methods for the treatment of diseases, disorders, or conditions that are modulated by matrix metalloproteinases (MMPs). The compounds can be selective MMP inhibitors, for example, selective inhibitors of MMP-2, MMP-9, and/or MMP-14. The disease, disorder, or condition can include, for example, stroke, neurological disorders, ophthalmological disorders, or wounds, such as chronic wounds or diabetic wounds. |
| 主权项 |
1. A compound of Formula I:wherein
R1 is —CH2—NHRa wherein Ra is H or (C1-C6)alkanoyl; —NH—C(═NH)—NH2; or J is S or O; G, T, and Q are each independently H, (C1-C6)alkyl, or —CN; each R2 is independently H, OH, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkanoyl, (C1-C6)alkanoyloxy, aryl, heteroaryl, carboxy, cyano, nitro, halo, trifluoromethyl, trifluoromethoxy, SRz, SO2N(Rz)2, NRzRz, or COORz; wherein each Rz is independently H, (C1-C6)alkyl, (C1-C6)alkanoyl, (C6-C10)aroyl, aryl, aryl(C1-C6)alkyl, heteroaryl, heteroaryl(C1-C6)alkyl, or optionally a nitrogen protecting group when Rz is covalently bonded to a nitrogen atom; and each n is independently 0, 1, 2, 3, or 4;or a salt thereof. |
