| 主权项 |
1. A method of treating or reducing the likelihood of developing a condition associated with cardiovascular disease, comprising administering to a subject in need thereof a therapeutically effective amount of an estrogen receptor ligand compound represented by the structure of Formula XIb: wherein R1, R2 and R3 are each, independently, hydrogen, —CH═CH2, halogen, hydroxyl, alkoxy, cyano, nitro, CF3, NH2, 4-methoxyphenyl, 4-hydroxyphenyl, alkenyl, NHR, N(R)2, alkyl, cycloalkyl, haloalkyl, aryl, benzyl or protected hydroxyl; R is alkyl or hydrogen; R′ is hydrogen or Alk; R″ is hydrogen or Alk; and Alk is a linear alkyl of 1-7 carbons or branched alkyl of 1-7 carbons;or its isomer, pharmaceutically acceptable salt, pharmaceutical product, crystal, N-oxide, or hydrate, or any combination thereof,wherein said condition associated with cardiovascular disease is cardiac hypertrophy, cardiomegaly, cardiac fibrosis, myocardial infarction, cardiomyopathy, cardiac failure, congestive heart disease, hypertension, stroke, coronary artery disease, atherosclerosis, vascular stenosis, vascular restenosis, obesity, hyperlipidemia, metabolic syndrome, insulin resistance, hyperglycemia, diabetes, or fatty liver disease. |
