Methods of monitoring adherence to lurasidone therapy

摘要

The present disclosure provides methods for monitoring subject (e.g., patient) adherence to lurasidone therapy, for example as a component of treating a subject for a mental health disorder such as schizophrenia.

主权项

1. A method for identifying a subject as non-compliant with a prescribed lurasidone therapy, the method comprising:
obtaining a fluid sample from a subject who has been prescribed lurasidone therapy; determining a level of M8/M9, M21, and/or M22 in the fluid sample; and identifying the subject as adherent to the prescribed lurasidone therapy if the fluid sample contains M8/M9, M21, and/or M22 above a threshold level but non-adherent if the fluid sample contains no M8/M9, M21, and/or M22 or an amount of M8/M9, M21, and/or M22 below a threshold level, wherein the fluid sample is a urine sample, and wherein the step of determining the level of the M8/M9, M21, and/or M22 in the fluid sample comprises mass spectrometry.