METHODS OF DIAGNOSING INCREASED RISK OF DEVELOPING MRSA

摘要

A method for diagnosing increased risk of developing Methicillin-resistant Staphylococcus aureus (MRSA) hospital-acquired (HA-MRSA) or community-acquired MRSA (CA-MRSA) which includes obtaining a biological sample from a subject, detecting in the sample a single nucleotide polymorphism (SNP) in the FAM129B gene at position 17 of SEQ ID NO 1, and comparing the nucleotide at position 17 of SEQ ID NO. 1 in the sample with the nucleotide at position 17 in SEQ ID NO. 1, wherein an adenine at position 17 of SEQ ID NO. 1 in the sample indicates an increased risk of developing MRSA or CA-MRSA in the subject.

主权项

1. A method of predicting or assessing the level of risk of a subject developing a Methicillin-resistant S. aureus (MRSA) infection comprising:
obtaining a biological sample from the subject, wherein said biological sample includes at least one oligonucleotide occupying a locus corresponding to position 17 of SEQ ID. NO 1; detecting the identity of at least one oligonucleotide occupying the locus corresponding to position 17 of SEQ ID. NO 1; determining whether at least one oligonucleotide occupying the locus corresponding to position 17 of SEQ ID. NO 1 is an adenine or a cytosine; and predicting and assessing the level of risk of the subject developing a MRSA, wherein an adenine occupying the locus corresponding to position 17 of SEQ ID. NO 1 indicates that the subject has a high risk of developing a MRSA infection and a cytosine occupying the locus corresponding to position 17 of SEQ ID. NO 1, indicates that the subject has a low risk of developing a MRSA infection.