发明名称 |
GENETICALLY MODIFIED ANIMALS HAVING INCREASED HEAT TOLERANCE |
摘要 |
Disclosed herein are genomically modified livestock animals and methods to provide them that express the SLICK phenotype. The animals disclosed herein express a truncated allele for the prolactin receptor (PRLR) gene. When expressed, the livestock animals produce a PRLR that is missing up to the terminal 148 amino acid (aa) residues of the protein all ranges and values within the explicitly stated range are contemplated: e.g., from 148 to 69. Animals expressing SLICK have superior thermoregulatory ability compared to non-slick animals and experience a less drastic depression in milk yield during the summer. |
申请公布号 |
US2017079251(A1) |
申请公布日期 |
2017.03.23 |
申请号 |
US201615270901 |
申请日期 |
2016.09.20 |
申请人 |
Recombinetics, Inc. |
发明人 |
Sonstegard Tad S.;Carlson Daniel F.;Fahrenkrug Scott C. |
分类号 |
A01K67/027;C07K14/715;C12N15/85 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
1. A livestock animal comprising a genetically modified prolactin receptor (PRLR) allele resulting in a truncated PRLR. |
地址 |
Saint Paul MN US |