| 发明名称 |
DERIVATIVES OF AMANITA TOXINS AND THEIR CONJUGATION TO A CELL BINDING MOLECULE |
| 摘要 |
Derivatives of Amernita toxins of Formula (I), wherein, formula (a) R 1, R 2, R 3, R 4, R 5, R 6, R 7, R 8, R 9, R 10, X, L, m, n and Q are defined herein. The preparation of the derivatives. The therapeutic use of the derivatives in the targeted treatment of cancers, autoimmune disorders, and infectious diseases. |
| 申请公布号 |
WO2017046658(A1) |
申请公布日期 |
2017.03.23 |
| 申请号 |
WO2016IB52246 |
申请日期 |
2016.04.20 |
| 申请人 |
HANGZHOU DAC BIOTECH CO, LTD |
发明人 |
ZHAO, Robert Yongxin;YANG, Qingliang;HUANG, Yuanyuan;GAI, Shun;YE, Hangbo;YANG, Chengyu;GUO, Huihui;ZHOU, Xiaomai;XIE, Hongsheng;TONG, Qianqian;CAO, Minjun;ZHAO, Linyao;JIA, Junxiang;LI, Wenjun;ZUO, Xiaotao;LIN, Chen;XU, Yifang;GUO, Zixiang |
| 分类号 |
A61K47/50;A61P35/00;C07K7/64 |
主分类号 |
A61K47/50 |
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