发明名称 |
ANTI-CD47 ANTIBODIES AND METHODS OF USE |
摘要 |
Disclosed herein are anti-CD47 antibody molecules, their manufacture and use in treating disorders associated with CD47 expression, for example, certain hematological cancers and solid tumors. |
申请公布号 |
US2017081407(A1) |
申请公布日期 |
2017.03.23 |
申请号 |
US201615271861 |
申请日期 |
2016.09.21 |
申请人 |
Erasmus University Medical Center ;Surface Oncology, Inc. |
发明人 |
Grosveld Frank;Palombella Vito;Holland Pamela M.;Paterson Alison;Hill Jonathan |
分类号 |
C07K16/28 |
主分类号 |
C07K16/28 |
代理机构 |
|
代理人 |
|
主权项 |
1. An isolated anti-CD47 antibody molecule, comprising a heavy chain complementarity determining region 1 (HC CDR1) of the amino acid sequence set forth in SEQ ID NO: 7, a heavy chain complementarity determining region 2 (HC CDR2) of the amino acid sequence set forth in SEQ ID NO: 8, a heavy chain complementarity determining region 3 (HC CDR3) of the amino acid sequence set forth in SEQ ID NO: 9, a light chain complementarity determining region 1 (LC CDR1) of the amino acid sequence set forth in SEQ ID NO: 10, a light chain complementarity determining region 2 (LC CDR2) of the amino acid sequence set forth in SEQ ID NO: 11, and a light chain complementarity determining region 3 (LC CDR3) of the amino acid sequence set forth in SEQ ID NO: 12. |
地址 |
Rotterdam NL |