CARBOXY PIPERIDYLACETAMIDE TRICYCLIC COMPOUNDS USEFUL FOR INHIBITION OF G-PROTEIN FUNCTION AND FOR TREATMENT OF PROLIFERATIVE DISEASES (FARNESYL PROTEIN TRANSFERASE INHIBITORS)

摘要

Compounds of formula (I) useful for inhibiting Ras function and therefore inhibiting or treating the abnormal growth of cells (farnesyl protein transferase inhibitors) are disclosed or an N-oxide thereof, or a pharmaceutically acceptable salt or solvate thereof, wherein: Q and T are independently selected from halo; W and V are independently selected from H and halo, provided that at least one of W and V is H; R1 is H or alkyl; X represents N, CH, or C when the double bond is present at the C-11 position; R is -OR3, -NR3R4 or -SR3; and R3 and R4 are independently selected from the group consisting of H, alkyl, arylalkyl, substituted arylalkyl, heteroarylalkyl and substituted heteroarylalkyl.