CATIONIC LIPID HAVING IMPROVED INTRACELLULAR KINETICS

摘要

Provided is a cationic lipid capable of achieving high intracellular expression efficiency when used as a nucleic acid delivery carrier. A compound represented by the formula (1)
wherein X a and X b are each independently X 1 or X 2 ;
s is 1 or 2,
R 4 is an alkyl group having 1 - 6 carbon atoms,
n a and n b are each independently 0 or 1,
R 1a and R 1b are each independently an alkylene group having 1 - 6 carbon atoms,
R 2a and R 2b are each independently an alkylene group having 1 - 6 carbon atoms,
Y a and Y b are each independently an ester bond, an amide bond, a carbamate bond, an ether bond or a urea bond, and
R 3a and R 3b are each independently a sterol residue, a liposoluble vitamin residue or an aliphatic hydrocarbon group having 12 - 22 carbon atoms.