发明名称 |
WEAKLY ACIDIC PH-RESPONSIVE PEPTIDE AND LIPOSOME CONTAINING SAME |
摘要 |
A problem to be solved by the present invention is to provide a peptide compound for producing a drug delivery carrier capable of releasing a target substance in a weakly acidic pH environment. The present invention provides a peptide compound comprising a hydrophilic amino acid block and a hydrophobic amino acid block; [1] the peptide compound containing 24 to 36 amino acids in total; [2] the hydrophilic amino acid block containing 4 to 10 amino acids in total and having an average hydropathy index of -3.0 to -1.0; and [3] the hydrophobic amino acid block containing 20 to 32 amino acids in total, containing one or more His residues, and having an average hydropathy index of 1.0 to 2.5. |
申请公布号 |
EP2910564(B1) |
申请公布日期 |
2017.03.22 |
申请号 |
EP20130848530 |
申请日期 |
2013.10.21 |
申请人 |
Taiho Pharmaceutical Co., Ltd. |
发明人 |
KOGURE, Kentaro;HAMA, Susumu |
分类号 |
C07K14/00;A61K9/00;A61K9/127;A61K47/42;A61P35/00 |
主分类号 |
C07K14/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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