| 摘要 |
The present invention relates to processes and intermediates useful for the manufacture of spiroindolone compounds such as (1′R,3′S)-5,7′-dichloro-6′-fluoro-3′-methyl-2′,3′,4′,9′-tetrahydrospiro[indoline-3,1′-pyrido[3,4-b]indol]-2-one and salts and hydrates and solvates thereof. |
| 主权项 |
1. A process for preparing a compound of formula (II), or a salt, solvate, or hydrate thereof,Comprising enzymatically converting a compound of formula (I) to compound of formula (II), or a salt, solvate or hydrate thereof,wherein:
the enzyme is SEQ ID NO: 134 the dashed line is a bond or absent; A is selected from C═O or C═NH; or when the dashed line is a double bond A-R8 is: Ra is C1-6 alkyl; R1 is H, —CH3, R4 and R7 are each, independently, H or —Cl; R5 is H, —OH, —CH3, —OCH3, —F, —Cl, —CF3 or —CN; R6 is H, —OH, —OCH3, —F or —Cl; R8 is H, —CH3, —CH2CH3, —CH2OH, —CO2H, —CO2CH2CH3 or —CF3; and n is 1 or 2. |
