| 发明名称 | Microbial strains and methods of making and using | ||
| 摘要 | Microbial strains are provided, as are methods of making and using such microbial strains. | ||
| 申请公布号 | US9598678(B2) | 申请公布日期 | 2017.03.21 |
| 申请号 | US201514689623 | 申请日期 | 2015.04.17 |
| 申请人 | NUtech Ventures | 发明人 | Murphy Nicole Roswitha Buan;Catlett Jennifer |
| 分类号 | C12N9/02;C12N1/00;C12N1/21;C12N15/00;C12P5/00;C12P5/02;C12N15/52 | 主分类号 | C12N9/02 |
| 代理机构 | Fish & Richardson P.C. | 代理人 | Fish & Richardson P.C. |
| 主权项 | 1. A mutant heterodisulfide reductase-like protein subunit B (HdrB) polypeptide, wherein the mutant HdrB polypeptide comprises an amino acid sequence with at least 95% sequence identity to the amino acid sequence of SEQ ID NO: 3, wherein methionine at the amino acid corresponding to position 249 of SEQ ID NO: 3 is substituted with valine in the mutant HdrB polypeptide, and wherein when the mutant HdrB polypeptide is combined with a heterodisulfide reductase-like protein subunit A (HdrA) polypeptide and a heterodisulfide reductase-like protein subunit C (HdrC) polypeptide forms an HdrABC enzyme that has heterodisulfide reductase activity. | ||
| 地址 | Lincoln NE US | ||