发明名称 Anti-hemagglutinin antibodies and methods of use
摘要 The present invention provides anti-hemagglutinin antibodies, compositions comprising anti-hemagglutinin antibodies, and methods of using the same.
申请公布号 US9598481(B2) 申请公布日期 2017.03.21
申请号 US201514725508 申请日期 2015.05.29
申请人 Genetech, Inc. 发明人 Xu Min;Balazs Mercedesz;Chai Ning;Chiang Nancy;Chiu Henry;Lin Zhonghua;Lupardus Patrick;Nakamura Gerald R.;Park Hyunjoo;Swem Lee
分类号 A61K39/42;A61K31/235;C07K16/10;A61K31/215;A61K31/24;A61K39/00 主分类号 A61K39/42
代理机构 代理人 Nesbitt James E.
主权项 1. A method for treating, inhibiting, or preventing influenza A virus infection in an individual in need thereof, the method comprising administering to the individual an effective amount of a composition comprising an anti-hemagglutinin monoclonal antibody that specifically binds influenza A virus hemagglutinin, wherein the antibody comprises three heavy chain hypervariable regions (HVR-H1, HVR-H2, and HVR-H3) and three light chain hypervariable regions (HVR-L1, HVR-L2, and HVR-L3), wherein: (a) HVR-H1 comprises the amino acid sequence of SEQ ID NO:191; (b) HVR-H2 comprises the amino acid sequence of SEQ ID NO:193; (c) HVR-H3 comprises the amino acid sequence of SEQ ID NO:194; (d) HVR-L1 comprises the amino acid sequence of SEQ ID NO:195; (e) HVR-L2 comprises the amino acid sequence of SEQ ID NO:196; and (f) HVR-L3 comprises the amino acid sequence of SEQ ID NO:197, thereby treating, inhibiting, or preventing influenza A virus infection in the individual.
地址 South San Francisco CA US