| 发明名称 | Modified cytosine polynucleotide oligomers and methods | ||
| 摘要 | Disclosed are modified cytosine bases that provide enhanced base-pairing affinity for guanine bases in polynucleotide hybridization complexes. Also disclosed are polynucleotide oligomers, polynucleotide hybridization complexes that comprise such modified cytosine bases. Also disclosed are various methods of use. For example, in some embodiments, modified polynucleotide oligomers disclosed herein can be used as primers and probes for nucleic acid amplification and/or detection. | ||
| 申请公布号 | US9598456(B2) | 申请公布日期 | 2017.03.21 |
| 申请号 | US201514673494 | 申请日期 | 2015.03.30 |
| 申请人 | Cepheid | 发明人 | Gall Alexander A.;Lokhov Sergey G.;Podyminogin Mikhail A.;Viazovkina Ekaterina V.;Lund Kevin Patrick |
| 分类号 | C07H19/04;C07H21/04;C12Q1/68;C07H19/10;C12N15/11;C07H19/06;C07K5/065 | 主分类号 | C07H19/04 |
| 代理机构 | Duane Morris LLP | 代理人 | Duane Morris LLP ;Ruppert Siegfried J.W. |
| 主权项 | 1. A polynucleotide oligomer comprising at least one modified base, wherein the at least one modified base is represented by the formula:and wherein Z is CH2 or O. | ||
| 地址 | Sunnyvale CA US | ||