Methods of preventing rejection of transplanted tissue by administering anti-CD40L antibody and HLA-E-bearing composition

摘要

A method is provided for preventing rejection by an immune system of a recipient subject of a tissue transplanted from a donor subject into the recipient subject without the need for long-term administration of non-specific immunosuppressive drugs.

主权项

1. A method for preventing rejection of a tissue transplanted from a donor subject into a recipient subject comprising:
a) administering to the recipient subject, prior to transplantation of the tissue, (i) a plurality of peripheral blood mononuclear cells (PBMCs) from the donor subject, wherein the PBMCs have been irradiated and do not proliferate in vivo, and (ii) an anti-CD40 ligand (anti-CD40L) antibody; and b) administering to the recipient subject, subsequent to transplantation of the tissue, (i) an HLA-E/IgG fusion protein, (ii) an HLA-E/type B peptide tetramer, (iii) a dendritic cell-derived, HLA-E-bearing exosome loaded with type B self peptides, or (iv) a membrane-bound, HLA-E-bearing composition comprising at least one type B peptide,
wherein the type B self peptide comprises the amino acid sequence set forth in SEQ ID NO: 1.