COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS

摘要

The present invention relates generally to the field of ocular therapeutics and the development thereof for use in humans or animals. More particularly, it relates to DHODH inhibitor compounds and their use for the treatment of ophthalmic diseases and disorders. The invention also relates to the local administration of such ophthalmic compositions, and in particular to their intravitreal administration. The invention relates also to controlled release formulations of therapeutically active agents, in particular of DHODH inhibitor compounds administered intraocularly, in particular in the posterior segment of the eye.

主权项

1. A method for treating an ocular disease with a dihydroorotate dehydrogenase (DHODH) inhibitor compound, wherein the compound is 3-(2,3,5,6-tetrafluoro-3′-trifluoromethoxy-biphenyM-ylcarbamoyl)-thiophene-2-carboxylic acid and is represented by the following formula:comprising the step of administering a therapeutically effective amount of the compound to a subject in need thereof.