发明名称 |
GLYCOSYLATED METABOLITES. |
摘要 |
The invention provides means and methods for detecting a glycosylated metabolite in a sample comprising adding to the sample a compound comprising a labelled glycosyl group coupled via an O-glycosidic bond to an aglycon with a specific structural formula wherein the glycosyl group comprises at least one isotope and/or a side chain being a label for detection, and wherein the sample is screened for the presence of a glycosylated metabolite with the glycosyl group other than a glucosylceramide. The invention further provides a method of treating a disorder caused by accumulation of a glycosylated metabolite other than glucosylceramide in a subject comprising administering to the subject in need thereof a therapeutically effective amount of a glucosylceramide synthase (GCS) inhibitor. |
申请公布号 |
WO2016209080(A3) |
申请公布日期 |
2017.03.16 |
申请号 |
WO2016NL50450 |
申请日期 |
2016.06.24 |
申请人 |
UNIVERSITEIT LEIDEN |
发明人 |
AERTS, Johannes Maria Franciscus Gerardus;OVERKLEEFT, Hermen Steven |
分类号 |
C12Q1/48;G01N33/68;G01N33/92 |
主分类号 |
C12Q1/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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