SYSTEMS AND METHODS FOR OBTAINING A DROPLET HAVING A DESIGNATED CONCENTRATION OF A SUBSTANCE-OF-INTEREST

摘要

Method includes providing a droplet actuator having a droplet-operations gap and a plurality of electrodes positioned along the droplet-operations gap. The method also includes positioning an input droplet in the droplet-operations gap. The input droplet has a starting concentration of a substance-of-interest. The method also includes conducting droplet operations within the droplet-operations gap using the electrodes to generate discrete dilution droplets that are formed from the input droplet. The dilution droplets and a remainder of the input droplet form a droplet set. At least two of the dilution droplets in the droplet set having different concentrations of the substance-of-interest. The method also includes combining a select number of the droplets from the droplet set to form an output droplet having a modified concentration that is substantially equal to a designated target concentration.

主权项

1. A method comprising:
providing a droplet actuator having a droplet-operations gap and a plurality of electrodes positioned along the droplet-operations gap; positioning an input droplet in the droplet-operations gap, the input droplet having a starting concentration of a substance-of-interest; conducting droplet operations within the droplet-operations gap using the electrodes to generate discrete dilution droplets that are formed from the input droplet, wherein the dilution droplets and a remainder of the input droplet form a droplet set, at least two of the dilution droplets in the droplet set having different concentrations of the substance-of-interest; and combining a select number of the droplets from the droplet set to form an output droplet having a modified concentration that is substantially equal to a designated target concentration.