CELL PENETRATING ANTI-GUANOSINE ANTIBODY BASED THERAPY FOR CANCERS WITH RAS MUTATIONS

摘要

It has been established that cancer cells with oncogenic mutants in the small GTPase K-Ras are susceptible to antibodies that bind intracellular guanosine, but delivery of antibodies into cells can be challenging. A subset of lupus autoantibodies is associated with anti-guanosine activity, and is capable of cellular penetration. These antibodies have potential as therapeutic agents targeted towards K-Ras associated malignancies.

主权项

1. A pharmaceutical composition comprising
a) one or more cell-penetrating anti-guanosine antibodies or antigen binding fragments or fusions or variants thereof in an amount effective to prevent, reduce or inhibit the growth or proliferation of cells having one or more amino acid mutations in the small GTPase K-Ras; and b) a sterile pharmaceutically acceptable excipient for administration to a human.