发明名称 |
CYCLOHEXYL-PYRIDINE DERIVATIVE |
摘要 |
A problem of the present invention is to provide a new compound which has NK 1 receptor antagonist activity ,whose CYP3A4 inhibitory activity is reduced compared to aprepitant, and which are useful for the prevention or treatment of cancer-chemotherapy-induced nausea and vomiting. That is, the present invention relates to cyclohexyl pyridine derivatives represented by the following formula (I) or a pharmaceutically acceptable salt thereof. wherein, ring A is 4-fluoro-2-methylphenyl or the like; X is a hydrogen atom or the like; R 1 is carboxymethyl or the like; R 2 is alkyl or the like; Y is 0-2 or the like; U is-N(CH 3 )COC(CH 3 ) 2 -3,5-bistrifluoromethylphenyl or the like. |
申请公布号 |
EP3141541(A1) |
申请公布日期 |
2017.03.15 |
申请号 |
EP20150789561 |
申请日期 |
2015.05.07 |
申请人 |
Kissei Pharmaceutical Co., Ltd. |
发明人 |
SHIMIZU, Kazuo;OHNO, Kohsuke;MIYAGI, Takashi;UENO, Yasunori;SUZUKI, Hikaru |
分类号 |
C07D213/75;A61K31/4418;A61P1/08;C07D213/76;C07D213/84 |
主分类号 |
C07D213/75 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|