MULTI-SPECIFIC ANTI-PSEUDOMONAS PSL AND PCRV BINDING MOLECULES AND USES THEREOF

摘要

The disclosure relates to combination therapies using anti-Pseudomonas PsI and PcrV bispedfic binding molecules and related compositions in prevention and treatment of Pseudomonas infection. Specifically, the bispedfic binding molecules comprising a binding domain that binds to Pseudomonas PsI and a binding domain that binds to Pseudomonas PcrV, wherein the PsI binding domain comprises a scFv fragment and the PcrV binding domain comprises an intact immunoglobulin, or the PsI binding domain comprises an intact immunoglobulin and the PcrV binding domain comprises a scFv fragment.