发明名称 |
FUCOIDANS AS LIGANDS FOR THE DIAGNOSIS OF DEGENERATIVE PATHOLOGIES |
摘要 |
The present invention relates to the diagnosis of clinical conditions characterized by undesirable and/or abnormal selectin expression. In particular, the invention provides for the use of fucoidans for the detection of selectins using imaging techniques including ultrasonography, scintigraphy and MRI. Selectin-targeted imaging agents are provided that comprise at least one fucoidan moiety associated with at least one detectable moiety. Methods and kits are described for using these imaging agents in the diagnosis of clinical conditions such as thrombosis, myocardial ischemia/reperfusion injury, stroke and ischemic brain trauma, neurodegenerative disorders, tumor metastasis and tumor growth, and rheumatoid arthritis. |
申请公布号 |
EP2416806(B8) |
申请公布日期 |
2017.03.15 |
申请号 |
EP20090786466 |
申请日期 |
2009.04.10 |
申请人 |
INSERM (Institut National de la Santé et de la Recherche Médicale);Université Paris 13 |
发明人 |
MICHEL, Jean-Baptiste;LETOURNEUR, Didier;CHAUBET, Frédéric;BACHELET, Laure;ROUZET, François;MEULEMANS, Alain |
分类号 |
A61K49/00;A61K49/04;A61K49/08;A61K49/12;A61K49/18;A61K49/22;A61K51/00;A61K51/04;A61K51/06;A61K103/10;B82Y5/00;G01N33/60 |
主分类号 |
A61K49/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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