Bioactive Compositions, Bioactive Eluting Devices and Methods of Use Thereof

摘要

One aspect provides a composition including triacetin, dimethyl sulfoxide and a bioactive. In one embodiment, the composition also includes a pharmaceutically acceptable carrier. Another aspect provides implantable medical devices including an elutable bioactive, triacetin and dimethyl sulfoxide. In certain embodiments, the combination of triacetin and dimethyl sulfoxide acts as a permeation enhancing agent by allowing the delivery of an increased amount of the bioactive to the tissue of a human or veterinary patient. Another aspect provides methods of delivering the bioactive to the tissue of the patient, including the step of administrating the composition to the patient or implanting the device within the patient.