发明名称 |
ADENOVIRUS COMPRISING AN ALBUMIN-BINDING MOIETY |
摘要 |
The invention relates to a recombinant adenovirus comprising an albumin-binding moiety on the outer surface of the adenoviral hexon protein, pharmaceutical compositions containing it and its medical use. Particularly, the invention relates to an oncolytic adenovirus comprising a sequence encoding an albumin-binding moiety inserted in a hypervariable region (HVR) of the hexon protein coding sequence and its use in the prevention and/or treatment of cancer. |
申请公布号 |
EP3137599(A1) |
申请公布日期 |
2017.03.08 |
申请号 |
EP20150720960 |
申请日期 |
2015.04.30 |
申请人 |
Fundació Institut d'Investigació Biomèdica de Bellvitge (IDIBELL);Institut Català d'Oncologia (ICO) |
发明人 |
ALEMANY BONASTRE, Ramon;ROJAS EXPÓSITO, Luis Alfonso |
分类号 |
C12N7/00;C07K14/075 |
主分类号 |
C12N7/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|