Devices and methods for noninvasive measurement of intracranial pressure

摘要

Provided are systems and methods for noninvasively assessing intracranial pressure by controllably osculating at least a portion of a subject's ocular globe while applying a force sufficient to collapse an intraocular blood vessel and correlating the collapse pressure to intracranial pressure. Also provided are ophthalmic components useful in ophthalmic imaging applications, such as retinal, corneal, and pupil imaging. The components may include an optical contact surface that has a radius of curvature that is greater than the radius of curvature of a subject's cornea.

主权项

1. A system for measuring intracranial pressure, comprising:
a pressure sensor; an optical imager; an ophthalmic component, comprising:
a deformable material;an osculating surface configured to contact a subject's cornea, sclera, eyelid, or any combination thereof;the deformable material and osculating surface partially defining a closed control volume enclosed within the ophthalmic component wherein the closed control volume is configured to retain a pressure within when in contact with a subject's cornea, sclera, eyelid, or any combination thereof;a passage placing the control volume in fluid communication with the pressure sensor so as to sense a pressure within the control volume;at least a portion of the osculating surface and a portion of the ophthalmic component opposite the osculating surface being configured to permit sufficient passage of light therethrough so as to allow optical imaging of a blood vessel within a subject's eye contacting the osculating surface; a pressurizing unit in fluid communication with the control volume, the pressurizing unit being configured to increase a pressure within the control volume to exert the osculating surface toward the subject's cornea, sclera, eyelid, or any combination thereof; and a processor operatively connected to the pressure sensor, the optical imager, and the pressurizing unit and configured to controllably pressurize the control volume with the pressurizing unit and estimate an intracranial pressure of a subject based on images of an intraocular blood vessel of the subject's eye through the ophthalmic component from the optical imager.