Method to compute and present brain amyloid in gray matter

摘要

An imaging work station (20) includes one or more processors programmed to receive (170) an image depicting a distribution of a radiotracer in a brain or other region of interest. The radiotracer includes at least one of [18F]-Flutemetamol, [18F]-Florbetaben, and [18F]-Florbetapir which highlights amyloid deposits. The image and a template or an MRI image of the region of interest which includes a segmented anatomical feature, such as gray matter, are registered (180) to a common space. A volume representation of the image which depicts the distribution of the radiotracer in the segmented gray matter and suppresses the radiotracer outside of the segmented anatomical feature in white matter is extracted (210).

主权项

1. An imaging work station comprising:
one or more processors programmed to:
receive an image depicting a distribution of a radiotracer in a region of interest that includes the brain;register the image to a common space defined by a template or an MRI image of the region of interest, the common space including a segmented anatomical feature representing a probability that each voxel is gray matter; andextract a volume representation of the image which depicts the distribution of the radiotracer in the segmented anatomical feature and suppresses the radiotracer outside of the segmented anatomical feature by combining each voxel of the image with the probability of the voxel being gray matter as represented by the registered common space.