Diagnosis of liver fibrosis and cirrhosis

摘要

This invention relates to method of diagnosing the presence and/or severity of a liver pathology and/or of monitoring the effectiveness of a curative treatment against a liver pathology in an individual, leading to a score, comprising the combination, of at least one blood test and of at least one data issued from a physical method of diagnosing liver fibrosis, said data being selected from the group consisting of medical imaging data and clinical measurements, said combination being performed through a mathematical function. This invention also relates to a method wherein the combination through a mathematical function, of at least one blood test and of at least one data issued from a physical method of diagnosing liver fibrosis, is performed at least twice and the at least two resulting scores are combined in an algorithm based on the diagnostic reliable intervals.

主权项

1. A microprocessor comprising a computer algorithm to perform a method of diagnosing the presence and/or severity of a liver pathology and/or of monitoring the effectiveness of a curative treatment against a liver pathology in an individual comprising:
obtaining a blood test score of at least one blood test from an individual, wherein the blood test comprises obtaining a blood sample from the individual and analyzing a marker for liver pathology in the blood sample to obtain a score; obtaining a result of using at least one measuring device to practice a non-invasive physical method for diagnosing liver fibrosis, wherein the physical method is further defined as comprising medical imaging and/or clinical measurement and is further defined as elastometry; and performing a mathematical function to combine the blood test score with the result of the physical method for diagnosing liver function to obtain a second score useful for the diagnosis of the presence and/or severity of a liver pathology and/or of monitoring the effectiveness of a curative treatment against a liver pathology in the individual.