Methods of treating diseases associated with high-fat diet and vitamin A deficiency using retinoic acid receptor agonists

摘要

This invention relates to pharmaceutical composition and methods of using vitamin A and/or RARB agonist for the treatment or prevention of diseases or conditions associated with high fat diet and/or vitamin deficiency. After smoking, high fat diet is said to be the second most lethal habit, causing 300,000 deaths each year in the U.S. alone. High fat diet leads to many health problems, including obesity, stroke, cancer, high blood pressure, diabetes, osteoarthritis, rheumatoid arthritis, multiple sclerosis, heart disease, and diseases in other organs such as liver and kidney.

主权项

1. A method of treating or preventing a pancreatic disease associated with a high fat diet or obesity, in a subject in need thereof, the method comprising administering to said subject an agonist of retinoic acid receptor-beta (RARβ), wherein said agonist is AC261066 or AC55649.