Multilayered tissue phantoms, fabrication methods, and use

摘要

A method for producing a multilayer tissue phantom involves successively forming at least two layers, each layer formed by depositing a viscous flowable material over a supporting element or over a previously formed layer of the phantom supported by the supporting element, selectively redistributing the material while material is solidifying to control a thickness distribution of the layer, and allowing the material to solidify sufficiently to apply a next layer. The supporting element supports the material in 2 or 3 directions and effectively molds a lumen of the tissue. The neighboring layers are of different composition and of chosen thickness to provide desired optical properties and mechanical properties of the phantom. The phantom may have selected attenuation and backscattering properties to mimic tissues for optical coherence tomography imaging.

主权项

1. A phantom comprising a chamber covered by a lumen, the lumen including at least 2 polymer-based layers having different compositions and exhibiting different scattering and attenuation values within optical and infrared regions of the electromagnetic spectrum, wherein one of the at least 2 polymer-based layers has a thickness less than 25 μm.