| 主权项 |
1. A method of treating chronic articular pain, which method comprises administering to a subject in need thereof an effective amount of a compound of formula (I) where X is (CH2)m or CH2O, where m is 1 or 2; p is 0 or 1; R1 is phenyl or a 5 or 6 membered heteroaryl group selected from the group consisting of imidazolyl, isoxazolyl, pyridinyl, pyridazinyl or pyrimidinyl, which phenyl or heteroaryl group is optionally substituted with 1 or 2 substituents selected from the group consisting of (C1-4)alkyl, (C1-4)alkoxy, halo, (CH2)nNR5R6 where R5 and R6 are independently H or (C1-4)alkyl and n is 0 or 1, pyrrolidinyl, morpholinyl, piperidinyl, pyrrolidin(C1-4)alkyl, morpholin(C1-4)alkyl, piperidin(C1-4)alkyl, pyrrolidin(C1-4)alkoxy, morpholin(C1-4)alkoxy, piperidin(C1-4)alkoxy wherein said pyrrolidinyl, morpholinyl or piperidinyl groups are optionally substituted with halo or (C1-4)alkyl, with the proviso that when R1 is phenyl or a 6 membered heteroaryl group, which phenyl or 6 membered heteroaryl group has a substitutent on the atom at the para position, said substituent is selected from the group consisting of methyl, ethyl, isopropyl, methoxy, halo or (CH2)nNR5R6 where R5 and R6 are methyl; R2 is H, methoxy, ethoxy or CH2OCH3; R3 is H, (C1-4)alkyl, (C2-4)alkenyl, halo, cyano, furanyl or pyrazolyl, which pyrazolyl is optionally substituted with 1 methyl group; R4 is H or (C1-4)alkyl; or a pharmaceutically acceptable salt thereof. |
