PLATINUM-LABELED PROBES FOR MASS CYTOMETRY

摘要

The present disclosure provides analyte-specific binding reagents conjugated with a platinum-containing moiety, e.g., cisplatin, and methods, compositions, and kits for their production and use in assays for analyte detection.

主权项

1. A method of detecting the presence of an analyte on a particle, the method comprising:
contacting a particle with an analyte-specific binding reagent conjugated to a platinum-containing moiety under conditions sufficient for analyte-specific binding of the analyte-specific binding reagent to its cognate analyte, wherein the platinum-containing moiety, when conjugated to the analyte-specific binding reagent, does not have covalent binding activity; and determining if platinum is associated with the particle, wherein when platinum is associated with the particle the analyte is present on the particle.